In vitro co-culture model of human monocyte-derived dendritic cells and T cells to evaluate the sensitization of dinitrochlorobenzene

Exposure to sensitizer has been suggested to be hazardous to human health, evaluation the sensitization of sensitizer is particularly important and urgently needed.Dendritic cells (DCs) exert an irreplaceable function in immunity, and the T cell receptor (TCR) repertoire is key to ensuring immune response to foreign antigens.We hypothesized that a

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Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations

Candida glabrata is an opportunistic fungal pathogen that currently ranks as the second most common cause of candidiasis.Although the mechanisms underlying virulence and drug resistance in C.glabrata are now starting to be elucidated, we still lack a good understanding of how this yeast adapts during the course of an infection.Outstanding questions

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Robust balanced optimization

An instance of a balanced optimization problem with vector costs consists of a ground set X, a cost-vector for every element of X, and a system of feasible subsets over X.The goal is to find a feasible subset that minimizes the so-called imbalance of values in every coordinate of the underlying vector costs.Balanced optimization problems with vecto

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